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Jerktonium
The Jerktonium only appears in It's a SpongeBob Christmas!. It is a chemical element in the periodic table discovered by Plankton. He includes it in the fruitcake that is given out to everybody in Bikini Bottom. The Jerktonium causes all Bikini Bottomites to become grumpy in order to make Plankton appear to be the nicest of them all. Everyone who tries the fruitcake gets big black and bushy eyebrows, dark bags under eyes and a five o'clock shadow. Plankton's first victim is SpongeBob, but SpongeBob is allergic to Jerktonium because of his pure heart. Soon Plankton gets tired and allows SpongeBob to deliver the fruitcake, causing everybody to get infected with Jerktonium.